Hepatitis B can cause nephropathy, called hepatitis B-associated nephropathy. Hepatitis B-associated nephropathy mainly manifests as proteinuria, hematuria or chronic nephropathy, nephrotic syndrome and other symptoms. One of the most typical pathological changes is membranous nephropathy. The incidence of hepatitis B virus infection with glomerulonephritis is about 6.8%-20.0%, and it is more common in children. The pathogenesis of this disease has not been elucidated, but a large number of research data show that hepatitis B-associated nephropathy is mainly caused by the following ways: 1. Immune damage caused by deposition of hepatitis B virus antigen-antibody complexes in the glomerulus: this way can cause disease in two forms: (1) circulating immune complexes: mainly after hepatitis B virus infection, its serum antibodies form immune complexes in the blood circulation and are deposited in (1) Circulating immune complexes: The main cause of disease is the formation of immune complexes in the circulation after infection with hepatitis B virus and its serum antibodies, which are deposited in the glomerular capillary collaterals and cause immune damage by activating complement. (2) In situ immune complexes: mainly the smaller molecular weight of hepatitis B virus e antigen crosses the basement membrane and binds with the hepatitis B virus e antibody first implanted under the glomerular epithelium to form in situ immune complexes, which are deposited under the glomerular epithelium and cause disease. 2, the virus directly infects the kidney cells: researchers found HBVDNA in the kidney tissue of patients with hepatitis B virus-associated nephritis, fully demonstrating that hepatitis B virus may directly infect the kidney. 3, hepatitis B virus infection leads to autoantibodies and cellular immune damage: autoimmune damage and immune regulatory function defects have a great relationship, hepatitis B virus infection can stimulate the body to produce a variety of autoantibodies such as: can DNA antibodies, anti-cellular skeleton components antibodies; hepatitis B virus infection of target cells will cause cytotoxic T cells to target cell immune damage, causing the body’s autoimmune response.