Constipation alternates with diarrhea, meaning that constipation occurs at one time and diarrhea at the next throughout the course of the disease, with constipation and diarrhea alternating sequentially. Constipation refers to a decrease in the frequency of bowel movements, for example, less than three bowel movements a week, accompanied by difficult, dry stools. Diarrhea is defined as an increase in the frequency of bowel movements, thin stools or stools containing undigested food residue, a frequency of >3 bowel movements/day, or a total stool weight of >200 g/day and a water content of >80%. Occurrence of constipation and diarrhea symptoms alternately need to differential diagnosis of intestinal tuberculosis, irritable bowel syndrome. Irritable bowel syndrome: patients gastroenteroscopy did not find any organic manifestations, no intestinal bacteria, viruses and other infections, often occurs when the patient’s work stress, emotional excitement. Treatment can use sedative patients patients anxiety, in addition to taking loperamide, montelukast and other drugs symptomatic treatment. Intestinal tuberculosis: patients with abdominal pain, change in bowel habits, abdominal mass as the main clinical manifestations, intestinal tuberculosis patients usually combined with open pulmonary tuberculosis. Treatment is based on anti-tuberculosis therapy, and drugs include streptomycin, isoniazid, pyrazinamide. Patients with alternating diarrhea and constipation should go to the gastroenterology department of the local hospital in a timely manner to improve gastroenteroscopy and follow the doctor’s instructions for treatment, and patients should not take medication on their own.