Hepatitis B minor tri-positive refers to positive hepatitis B surface antigen, positive hepatitis B e antibody and positive hepatitis B core antibody. Generally speaking, when hepatitis B minor triple positive, the virus may be low and the liver function is normal, which is a good state. However, when the hepatitis B virus zone C mutates, at this time hepatitis B minor tri-positive, often the viral load is also relatively high, there will be continuous slight damage to the liver, and over time, it is also easy to progress to cirrhosis or even liver tumors. Therefore, for hepatitis B small third-positive, high viral load, need to be closely monitored, once found liver function is not normal, eligible for anti-hepatitis B virus treatment, need to be standardized anti-hepatitis B virus and other comprehensive treatment. Hepatitis B virus carriers need regular checkups of hepatitis B DNA, quantitative hepatic function of hepatitis B V, abdominal ultrasound, methemoglobin and other indicators every 3-6 months.