Surgery is generally not necessary for advanced liver cancer at 70 years old, but chemotherapy, targeted therapy, immunotherapy and other treatments should be targeted under doctor’s assessment. First of all, due to age and physical condition, most of 70-year-old people are physically difficult to tolerate liver cancer resection surgery. Secondly, advanced liver cancer often has metastasis, which is difficult to be completely removed by surgery. Moreover, advanced liver cancer is also accompanied with malignant disease, which may lead to malnutrition, generalized emaciation, weakness, etc., and is not suitable for surgery. The treatment of advanced liver cancer mainly focuses on prolonging the survival period and improving the quality of life. Chemotherapy drugs such as oxaliplatin and capecitabine can be chosen, as well as oral targeted therapy with drugs such as sorafenib and lenvatinib, and immunotherapy drugs such as atilizumab. Patients with advanced liver cancer at the age of 70 need to go to the hospital in time to get a clear diagnosis and treatment plan, use drugs under the guidance of doctors and avoid self-medication.