Creatinine 500μmol/L can usually be treated conservatively. Blood creatinine above 500μmol/L is the renal failure stage of chronic renal insufficiency, not yet to the stage of uremia. At present, if there are no special circumstances, no obvious digestive symptoms, no obvious acidosis, no serious hyperkalemia, no obvious respiratory distress, etc., you can continue conservative treatment. Creatinine 500μmol/L indicates that renal function is severely impaired, to comprehensively assess the specific condition and etiology of the patient, to develop a targeted treatment program, in addition to active treatment of the primary disease, should also be good control of blood pressure, blood glucose, lipids, and other risk factors, and at the same time should be appropriate exercise, a reasonable diet, and to avoid the use of nephrotoxic drugs. It is recommended that patients with abnormal creatinine should go to the hospital in time, and under the doctor’s guidance, actively treat and regularly review their condition to avoid the progression of the disease.