Hepatitis B with cirrhosis in the decompensated stage is very difficult to slowly recover to cure, but the progress of the disease can be controlled through treatment. In the decompensated stage of cirrhosis, liver function is seriously impaired, liver fibrosis will occur, and the structure of the liver itself will be damaged, and this process is difficult to be reversed and cured even through standardized treatment, and may further deteriorate and aggravate. Therefore, it is very difficult to slowly recover from the decompensated stage of hepatitis B with cirrhosis to a cure. Patients diagnosed with cirrhosis combined with hepatitis B can be treated with entecavir against hepatitis B, liver-protecting drugs, such as reduced glutathione, adenosylmethionine and other liver-protecting treatments, and liver transplantation can also be considered, and the progression of the disease can be controlled through standardized treatment. Patients diagnosed with cirrhosis with hepatitis B should actively cooperate with doctors for treatment and maintain a healthy lifestyle and diet to help improve the prognosis.