Gallbladder stones are mainly cholesterol stones or a mixture of cholesterol-based stones. Most patients can be asymptomatic, called asymptomatic gallbladder stones. They are only discovered during a physical examination. Many people have gallbladder stones but have no symptoms, so they do not pay attention to them. The typical symptom of gallbladder stones is biliary colic, which is notable only in a minority of patients. Others often present as symptoms of acute cholecystitis or chronic cholecystitis. The main clinical manifestations include: a. Epigastric vague pain: Most patients only feel vague pain in the upper abdomen or right upper abdomen when they over-eat, eat high-fat food, work under stress or have poor rest, or have fullness, belching, erratic, etc., which can be easily misdiagnosed as “stomach disease” and must be diagnosed differently. Biliary colic: The typical manifestation is that the patient often has colic due to contraction of the gallbladder or stone displacement after a full meal, eating fatty food or during sleep when the position changes, plus vagal nerve excitement, stone imbedding in the abdomen or neck of the gallbladder, gallbladder evacuation is obstructed, the pressure in the gallbladder rises, and the gallbladder strongly contracts. The pain is located in the right upper abdomen or epigastrium and is paroxysmal, or the pain may increase in paroxysms, radiating to the right scapula and back, and may be accompanied by nausea and vomiting. Some patients are unable to name the exact site of pain because of the severity of the pain. After the first appearance of biliary colic, about 70% of patients will have a recurrence within a year, and the frequency of subsequent attacks will increase. Gallbladder effusion: When gallbladder stones are embedded for a long time or obstruct the gallbladder duct but not combined with infection, the gallbladder mucosa absorbs bile pigments from the bile. Secrete mucus material, forming gallbladder effusion. The fluid is clear and colorless, also known as white bile. Mirizzi’s syndrome: Mirizzi’s syndrome is a special type of gallbladder stone, which is caused by the persistent embedment in the neck of gallbladder and large gallbladder duct stones compressing the common hepatic duct due to the excessive length of the gallbladder duct and the common hepatic duct or the low confluence of the gallbladder duct and the common hepatic duct, resulting in the narrowing of the common hepatic duct. The recurrent inflammatory episodes lead to fistula of the common hepatic duct, loss of the cystic duct and partial or complete blockage of the common duct by stones. The clinical presentation is recurrent cholecystitis and cholangitis with marked obstructive jaundice. Biliary imaging shows an enlarged gallbladder, dilated common hepatic duct, and normal common bile duct. V. Other: 1. Small stones may enter the common bile duct through the cystic duct and become common bile duct stones; this time can lead to jaundice. 2, rarely cause jaundice, less; because gallbladder stones do not lead to obstruction of the common bile duct, bile outflow is not obstructed, jaundice will not occur. 3.Stones and long-term inflammatory stimulation can induce gallbladder cancer. 4.Stones in the common bile duct are embedded in the jugular abdomen through the sphincter of Oddi, leading to pancreatitis, which is called biliary pancreatitis; this is the most common cause of acute pancreatitis in China. 5. Inflammation and chronic perforation of the gallbladder caused by stone compression can result in cholecystoduodenal fistula or cholecystocolic fistula, and large stones entering the intestine through the fistula causing intestinal obstruction called gallstone intestinal obstruction.