The survival of untreated neonatal cholestasis is unpredictable and depends on the severity of the cholestasis, which if left untreated can severely affect the liver function of the neonate. There are many causes of neonatal cholestasis, such as genetic factors, infectious factors, congenital developmental malformation factors, etc. Generally, jaundice deepens progressively in neonates within 1~2 weeks of birth, with potter’s earth-colored stools and strong tea-colored urine. As the disease progresses, it will seriously affect the liver function of newborns, and can develop into biliary cirrhosis and portal hypertension in 2~3 months, which will seriously affect the life of newborns. It is worth noting that neonatal cholestasis is not incurable, and after diagnosis of neonatal cholestasis, you should seek timely medical treatment, choose the correct treatment to prevent the progression of the disease.