If depressed patients’ condition reaches moderate or above, they are generally more likely to have somatic symptoms, such as general weakness and peripheral fatigue, mainly due to disorders of neurotransmitter secretion, prolonged bed rest and insufficient nutritional intake, etc. At this time, they need to make self-adjustment and intervene in treatment from diet, medication, psychological and physical aspects. Causes: 1. Disorders of neurotransmitter secretion: due to disorders of neurotransmitter secretion in the brain of depression patients, dopamine, 5-hydroxytryptamine and other neurotransmitter secretion is reduced, resulting in autonomic dysfunction causing somatic symptoms; 2. Prolonged bed rest: due to depression patients due to physical inactivity or pessimism, they will be bed-ridden for a long time, due to reduced physical activity may appear general weakness, severe fatigue Inadequate nutritional intake: depressed patients are often prone to nausea, vomiting, loss of appetite and other symptoms, which may lead to inadequate intake of nutrients and general weakness, severe fatigue and other symptoms. Second, treatment: 1, self-adjustment: need to encourage depression patients to go out more, sunshine, etc., can relieve depression. You can also exercise more, which can also relieve depression; 2, medication: common treatment drugs mainly include sertraline hydrochloride, fluoxetine hydrochloride, paroxetine hydrochloride, duloxetine hydrochloride, venlafaxine hydrochloride extended-release capsules, escitalopram oxalate tablets, mirtazapine, agomelatine and other drugs to give treatment; 3, psychotherapy: common psychotherapy methods mainly include cognitive behavioral therapy, psychoanalytic therapy 4.Physical therapy: Commonly used physical therapy methods include music therapy, relaxation therapy, floating feedback therapy, biofeedback therapy, transcranial magnetic stimulation therapy and other treatment methods, which can also relieve depression symptoms.