Cavernous sclerosis is also called cavernous sclerosis. Generally there is no topical medicine, the treatment needs to be decided according to the cause and condition of the patient, the main treatment measures include drug treatment and surgical treatment, physical therapy and so on. 1. Drug treatment: to stop the development of the disease. Clinical treatment can take oral drug therapy, commonly used drugs are anti-estrogen drugs, such drugs can resist tissue fibrosis, such as tamoxifen, can also take vitamin E, antioxidant treatment. 2. Surgery: Surgery is considered for patients with serious condition, including fibrous plaque excision, patch and corrective surgery. However, the effect of surgery is not ideal, and it is easy to recur after surgery. 3. Physical therapy: including tissue ammonium ion therapy, ultrasonic therapy and so on. Physical therapy can promote the softening and absorption of penile sclerosis, which is helpful in relieving patients’ symptoms. Patients with penile sclerosis also need to pay special attention to the fact that in daily life, they should try to avoid strenuous sex, avoid spicy and stimulating food, and strictly prohibit alcohol abuse, so as not to aggravate the degree of damage to the penile sclerosis. Once penile sclerosis occurs, the patient needs to seek medical treatment in time, the doctor will first screen the cause of the disease, such as whether suffering from diabetes, whether improper sexual intercourse caused by the damage and so on. At the same time, the doctor will also diagnose the scope, severity and duration of sclerosis, and then according to the cause of the disease and the diagnosis, the appropriate treatment. Medications are recommended to be taken as prescribed by the doctor.