Human papillomavirus, or HPV. HPV is not infectious, but having high-grade squamous epitheliopathy is still serious and needs to be taken seriously. High-grade squamous epitheliopathy is a pathologic finding of the cervix, i.e., CIN grade III, an abnormally proliferative type of cervical lesion, which is precancerous and not cancerous, but only has a tendency to become cancerous. Although the vast majority of cervical cancers are caused by HPV infection, there are a few specific cervical cancers that are not related to HPV, such as small cell carcinoma of the cervix and clear cell carcinoma. When high-grade squamous epitheliopathy is detected, it needs to be taken seriously. If no intervention is made to treat it and the cervical lesion is allowed to continue to develop, it is very likely to develop into cervical cancer. Therefore, when no HPV infection is detected, but there is high-grade squamous epitheliopathy, it is recommended to consult a doctor in a timely manner, complete the relevant examinations, clarify the cause of the disease under the guidance of a professional doctor, and take timely treatment measures to avoid delaying the condition.