The timeframe for the production of antibodies after hepatitis B vaccination varies from person to person, and it usually takes 1 month after the first dose of hepatitis B vaccine to produce antibodies. Hepatitis B vaccine requires a total of three vaccinations, one each at months 0, 1 and 6. The first dose of hepatitis B vaccine usually stimulates the body to produce an immune response. The second and third vaccinations will further strengthen the immunization, causing the body to produce higher titers of antibodies. The time for antibody production after hepatitis B vaccination is related to the individual’s physical condition. Usually, antibodies will be produced about 1 month after the first vaccination, achieving partial prevention of hepatitis B virus infection. After the full course of three doses, most vaccinated persons can produce sufficient titers of antibodies to prevent hepatitis B virus infection.