A 95% distal stenosis of the heart, generally defined as a 95% narrowing of the distal part of the heart’s coronary arteries, is serious and can cause angina pectoris, myocardial infarction, and heart failure. The coronary arteries of the heart are the blood vessels that provide blood and oxygen supply to the heart’s cardiomyocytes, and only when the coronary arteries are clear can the cardiomyocytes have enough blood and oxygen to work normally. If the distal part of the coronary artery is narrowed by 95%, it will lead to ischemia and hypoxia of the heart muscle cells in the corresponding area, which will cause angina or even myocardial infarction due to ischemia and hypoxia of this small part of the heart muscle, and a large myocardial infarction may lead to heart failure. Therefore, 95% of distal coronary artery stenosis is very serious and requires prompt medical attention and interventional therapy or cardiac bypass surgery to improve and relieve symptoms.