Ulcers at the end of the ileum can be seen in various intestinal diseases such as ulcerative intestinal tuberculosis, Crohn’s disease or intestinal typhoid fever. 1. Ulcerative intestinal tuberculosis: can occur in the ileocecal part or distal ileum, caused by Mycobacterium tuberculosis infection, can make the intestinal wall of the collection of lymphoid tissue or isolated lymphoid follicles of congestion, edema, the formation of caseous necrosis rupture can be gradually formed after the depth of the ulcers vary, the edge of the irregularity of the ulcers, often caused by diarrhea, not accompanied by the urgency of the post-traumatic stress (discomfort in the lower abdomen, would like to relieve the bowel movement, stool, there is a sense of incomplete defecation after defecation), more than the absence of pus and blood. 2. Crohn’s disease: most common in the terminal ileum and adjacent colon, the formation of fissure ulcers, deep to the submucosal layer, muscle layer and even the plasma membrane layer, the mucous membrane is prominent edema with cobblestone-like changes, more than caused by abdominal pain, diarrhea and other manifestations. 3. Intestinal typhoid fever: typhoid bacillus infection, invasion of the terminal ileum lymph nodes or lymphoid follicles, resulting in inflammatory edema, gradual necrosis, the formation of ulcers, can cause perforation. After checking and finding the ulcer at the end of the ileum, timely identify the cause of the disease, and treat the cause of the disease in order to avoid delaying the condition.