Preterm infants with cold hands can be seen in physiological phenomena, pathological conditions (such as pneumonia, etc.), whether there is a problem needs to be judged according to the baby’s condition, such as severe pneumonia fever can occur when the above phenomenon is not normal. 1. Physiological phenomenon: premature babies have imperfect development of thermoregulatory center function, thin subcutaneous fat, relatively large surface area, easy to dissipate heat, when the ambient temperature is low or too little wrapping can be cold hands, pay attention to adjusting the indoor temperature or increase the warmth of the cold hands can be relieved. 2. pathological conditions: in some diseases, such as pneumonia, intracranial infections, etc., the course of the disease can appear fever, peripheral vasoconstriction, the baby can appear cold hands phenomenon, or pneumonia, intracranial infections, severe infectious shock, peripheral circulation is poor, can also appear the above phenomenon, belongs to the critical illness. Such babies are considered “problematic”. It is recommended that preterm babies with cold hands be seen by a specialist for evaluation and judgment.