Bumps and hard knots in the thumb joint may be caused by stenosing tenosynovitis, tenosynovial cysts, bursitis, etc. General treatment, physiotherapy, medication and surgery are feasible to alleviate the symptoms. 1. Stenosing tenosynovitis: it may be a chronic aseptic inflammation of the tendon sheath caused by mechanical friction, which is common in people who use their fingers for a long period of time, rapidly and with excessive force. In the early stage, braking and resting can be taken to avoid prolonged use of fingers. Oral non-steroidal anti-inflammatory drugs, such as ibuprofen, celecoxib, meloxicam, etc., to relieve pain symptoms. 2. Tendon sheath cysts: Tendon sheath cysts are benign lumps near the joints, which may be related to long-term injuries and joint degeneration. If mild pain, oral non-steroidal anti-inflammatory drugs, such as ibuprofen, aspirin, etc., is conducive to anti-inflammatory and pain relief. If the cyst continues to increase in size or the pain symptoms worsen, surgical treatment is required. 3. Bursitis: Bursitis is an inflammation caused by some kind of irritation leading to bursa damage, and may appear as a hard knot in the thumb joint that is painful to press. If the symptoms are mild, you can reduce the amount of activity, localized hot compresses and other treatments. Physical therapy such as ultrasound can also be used, which is conducive to eliminating bursal inflammation. If necessary, bursa resection and other surgical treatment can be taken. All of the above medications should be used under the guidance of a doctor, avoid self-medication. If the above symptoms occur, it is recommended to go to the regular hospital in time, and early formal treatment.