The best indicators for the clinical diagnosis of hypercortisolism are elevated or rhythmic changes in plasma cortisol and adrenal morphologic changes. 1. Plasma cortisol measurement: elevated plasma cortisol or rhythmic changes help in the diagnosis of hypercortisolism and can be used as the preferred screening method. 2. 24h urine: 17-OH, 17-KS increase suggests cortisolism, especially 17-OH increase is more sensitive, such as 17-OH, 17-KS significant elevation, should pay attention to the presence of malignant changes. 3. Imaging examination: ultrasound imaging is one of the effective methods to diagnose adrenal diseases, which is simple, rapid and economical, but the accuracy rate is low due to the influence of many factors such as operation level, experience and sensitivity of ultrasound model; CT is a reliable diagnostic technique to observe the anatomical morphology of adrenal glands and localization of tumors, with high accuracy rate, which is of great significance to the diagnosis of adrenal diseases. If you suspect the existence of cortisolism, you should go to the hospital in time, under the guidance of the doctor to check and judge.