Amebic granuloma of the cecum is caused by long-term untreated lesions that produce a large amount of fibrous tissue, inflammatory infiltration and edema of the mesentery and intestinal wall, resulting in granuloma-like masses and narrowing of the intestinal lumen or impaired movement of the intestinal wall causing intestinal obstruction. In the acute phase of the lesion, most of the elevated grayish-yellow caps of pinhead-sized necrosis or shallow ulcers are visible on the surface of the intestinal mucosa in the early stage. As the lesion progresses, the necrotic foci increase in size and take the shape of round buttons surrounded by a hemorrhagic band. What tests are needed for amebic granuloma of the appendix? I. Physical examination Taking a history gives us an initial impression and insight, and also guides us to have an idea of the nature of the disease. Laboratory examinations Laboratory examinations must be based on the objective materials learned from the history and physical examination for generalization and analysis, from which several diagnostic possibilities are proposed, and then further consideration is given to those laboratory examinations to confirm the diagnosis. For example, the diagnosis of cecum amebic granuloma is often clear only when the pathological examination after resection reveals the presence of most trophozoites and encapsulation in the lesion tissue. The mucosa between the ulcers is normal or shows only mild cicatricial inflammation. In severe cases, neighboring ulcers may form a submucosal channel-like communication with each other, and the surface mucosa may be necrotic and detached in large pieces, forming a huge ulcer with submerged margins, which can be 8-12 cm in diameter. Pay attention to the prevention of amoebic and trematode infections. Actively treat the primary disease, be sure to use medication under the guidance of a doctor: if the medication is not right, it may aggravate the disease. Exercise regularly to enhance physical fitness; ensure adequate sleep; eat more vitamin-rich foods; learn to regulate your emotions, immunity will be enhanced when you are in a happy mood.