Thrombocytopenia in children refers to a platelet count of <100×10^9/L in the blood, which should be promptly consulted in the hematology department of the hospital, and the treatment includes medication and so on. Children’s platelets may be caused by certain drugs, may be caused by infection, and may be caused by blood system diseases. Before treatment, it is first necessary to improve the relevant examination to clarify the cause of the disease, and then carry out the treatment for the cause. 1. Drug factors: children who use certain drugs such as sulfa, aminopyrine, etc., may lead to platelet destruction or excessive consumption, thus causing thrombocytopenia. Generally, after stopping the use of drugs, the lowered platelets will gradually rise to the normal range. 2. Infection: When viruses, bacteria and other pathogens invade the human body, the body, through the immune mechanism, produces antiplatelet antibodies, which may lead to excessive destruction of platelets and decrease in their number. Treatment by actively treating the primary disease, anti-infection treatment as appropriate, such as the treatment of bacterial infections, commonly used drugs such as cefaclor and amoxicillin, platelets can gradually return to normal. 3. Blood system diseases: such as leukemia, primary thrombocytopenic purpura, etc., commonly used drugs such as prednisone, cyclophosphamide, etc., during the use of drugs need to pay attention to the observation of the side effects of drugs. For those with heavy bleeding and spontaneous bleeding tendency, platelets and high-dose gammaglobulin should also be transfused. After treatment, platelets will gradually rise. Thrombocytopenia in children should be consulted in time for a clear diagnosis and standardized treatment according to the doctor’s instructions.