Mixed ground-glass nodules with clear margins and small vacuoles are not particularly serious. The specific severity should be further clarified with pathologic puncture examination by a specialized doctor. Mixed ground glass nodules with clear margins and small vacuoles are more likely to be benign and are commonly associated with lung infections, old lesions or tuberculosis, which are not particularly serious. However, the presence of vacuolar signs in mixed ground glass nodules does not completely exclude the possibility of malignant nodules, and further puncture examination of lung nodules should be performed to clarify the nature of the nodules. If the CT examination of the lungs reveals mixed ground glass nodules with clear margins and small vacuoles, it is recommended to cooperate with a specialized doctor to improve the relevant examinations as soon as possible, so as to exclude the possibility of malignant nodules in a timely manner. If the nodule is benign, it is also necessary to go to the hospital regularly for review and closely observe the changes in the shape and size of the mixed ground-glass nodule. Once abnormal changes are found, you should cooperate with your doctor for standardized treatment as soon as possible.