SLE cannot be cured at present, and treatment should be individualized, and long-term remission can be achieved after reasonable treatment. Its treatment mainly includes general treatment, symptomatic treatment and drug treatment. 1. General treatment: ① Psychological treatment to make patients optimistic about the disease; ② Bed rest during the acute activity period, chronic patients with stable disease can work appropriately, but do not overwork; ③ Early detection and treatment of infection; ④ Avoid using contraceptives and other drugs that may induce lupus; ⑤ Avoid strong sunlight exposure and ultraviolet radiation; ⑥ Immunization can be done only during the remission period, and live vaccines are not used as much as possible. 2. Symptomatic treatment: Non-steroidal anti-inflammatory drugs can be supplemented for fever and joint pain, and corresponding treatment should be given to those with hypertension, dyslipidemia, diabetes, osteoporosis, etc. For the neuropsychiatric symptoms of SLE, corresponding treatment such as cranial pressure lowering, antiepileptic and antidepressant can be given. 3. Drug therapy: glucocorticoid plus immunosuppressant is still the main treatment plan. ①Glucocorticoid: during the induction remission period, prednisone is used according to the condition, and the dose is slowly reduced after the condition is stabilized, and if the condition allows, a small dose is used for long-term maintenance. In the presence of acute progressive damage to important organs, hormone shock therapy can be applied. ②Immunosuppressants: Most patients with SLE, especially when the disease is active, need to choose immunosuppressant combination therapy, which is beneficial to better control the activity of SLE, protect the function of important organs, reduce relapse, as well as reduce the need for long-term hormones and side effects. ③Other drug treatment: When the disease is critical or difficult to treat, intravenous high-dose immunoglobulin, plasma exchange, hematopoietic stem cell or mesenchymal stem cell transplantation can be selected according to the situation. ④ Treatment of combined antiphospholipid antibody syndrome: Aspirin or warfarin anti-platelet anticoagulation therapy needs to be applied according to the antiphospholipid antibody titer and clinical situation. Therefore, the treatment of SLE has the above three main aspects, and how to treat it should be individualized according to the patient’s specific situation.