In endocrinology consultations and outpatient clinics, we encounter some diabetic patients who are unintentionally found to have gallbladder stones by ultrasound or CT, and the patients do not have any clinical symptoms. Some people think that cholecystectomy is needed, if not, the infection will be very heavy during the gallbladder infection attack because of having diabetes and the risk is increased. Others believe that surgery is not needed and that if operated instead it can cause infections, such as abdominal and incisional infections. Some materials and books recommend cholecystectomy in diabetic patients with asymptomatic gallbladder stones, while others do not specify and advocate neither removal of the gallbladder nor non-removal of the gallbladder. As a result, some patients are overwhelmed, and even some non-specialists are unsure of how to respond. So how should this situation be handled? The authors have reviewed some authoritative literature and books, and then combined their 26 years of experience in treating tens of thousands of gallbladder stone patients to give the following suggestions for reference only. Diabetic patients with asymptomatic gallbladder stones do not require surgery, and prophylactic cholecystectomy is not beneficial to the patient, but increases the risk of surgery and anesthesia and the discomfort caused by gallbladder removal, such as increased frequency of stools. Guidelines for gallbladder removal in diabetic patients with gallbladder stones are the same as for the general population.