I. Composition and pharmacological effects of Smecta
Smecta, the English name “Smecta”. It contains double octahedral montmorillonite micro powder. It has a laminar structure and non-uniform charge distribution, which has a strong fixing and inhibiting effect on viruses and germs in the digestive tract and the toxins they produce; it has a strong covering ability on the digestive tract mucosa, and improves the defense function of the mucosal barrier against attack factors by combining with mucus glycoproteins and repairing both qualitatively and quantitatively. Indicated for: ① Symptomatic treatment of esophagitis, gastritis, colitis, functional colon disease. ②Acute and chronic diarrhea in adults and children, especially effective in acute diarrhea in children.
Simethicone is a silica-aluminate, the main component of which is octahedral montmorillonite particles with a powder size of 1 to 3 μm, which has a strong ability to cover the mucosa of the digestive tract and can be maintained for as long as 6h. PharmacokineticsThe drug does not enter the blood circulation system and is excreted along with the fixed attack factor with the digestive tract’s own peristalsis. The drug does not affect X-ray examinations, does not change the color of the stool and does not alter the normal bowel movements. It is derived from pure natural minerals, with high safety and light side effects.
Second, the clinical application of Simethicone
Simethicone is a gastrointestinal mucosal protective agent with strong adsorption ability, which is commonly used in the treatment of pediatric diarrhea. In fact, there are many other uses of Simethicone in the treatment of pediatric diseases.
(a) Neonatal jaundice Simethicone can reduce the absorption of bilirubin and promote the excretion of bilirubin from the intestine.
(ii) Lactose intolerance in infants Semicarb can improve the symptoms of children and promote the recovery of lactose tolerance, so it is recommended as one of the first choice drugs for lactose intolerance in infants. Combined with lactase, vitamin B1 and vitamin B6, it can enhance the efficacy and promote further improvement of symptoms. It is used as 1/3 packet each time for 7-10 days.
(iii) Neonatal gastrointestinal bleeding For neonatal gastrointestinal bleeding caused by various reasons, while actively treating the primary disease, the administration of Simethicone has a certain hemostatic effect.
(iv) Recurrent abdominal pain in pediatric patients Recurrent abdominal pain in pediatric patients is caused by spasm of intestinal smooth muscle and is often recurrent and common in pediatric outpatient clinics. The number of episodes of abdominal pain can be reduced by the treatment of Simethicone. In 50 cases treated with Smitha, the effective rate reached 94%, which was significantly better than that of belladonna or atropine group.
(E) Chronic prolonged diarrhea in infants and young children Semicarb can reduce intestinal secretion, protect intestinal mucosa, and promote the regression of diarrhea. If oral administration is not effective, the combination of enema with gentamicin can be considered for better effect.
(F) pediatric mycobacterial enteritis anti-mycobacterial drugs and combined with Simethicone, the efficacy is reliable, with an efficiency of more than 95%.
(vii) Stomatitis and pediatric stomatitis Topical application of Simethicone for the treatment of pediatric stomatitis and stomatitis ulcers has obvious pain-relieving effect and can promote the speed of recovery of oral inflammation and ulcers, with good effect, and can be used as a regular drug.
Third, the correct use of Similac
The method of taking Similac is directly related to its efficacy. Many parents and even doctors do not know how to take Similast properly. The following issues should be noted when taking Similast
(i) Dosage Children: under 1 year old, 1 bag per day, divided into 3 doses: 1-2 years old: 1-2 bags per day, divided into 3 doses; over 2 years old: 2-3 bags per day, divided into 3 doses.
(B) the time of taking should be forked with the time of eating, to be taken after the basic emptying of the stomach, and do not eat for at least 2 to 3 hours after taking the drug, otherwise it will affect the role of drugs. It is ineffective to take Simethicone before or half an hour after a meal because it cannot cover the mucous membrane evenly and its effect cannot be played.
(iii) Dosing method A sachet of medicine (3 g) needs to be added with 50 ml of water for the medicine to work best. Some parents even pour the medicine in a spoon, add only a little water, stir into a thick paste, and give it to their children to eat. This is not only ineffective, but can also lead to constipation. Some children may have dry stools when they start taking Similac for 1 to 2 days, it does not matter, just add 10 ml of water, that is, at a ratio of 1:60, and change to a ratio of 1:50 after 2 to 3 days of adaptation.
（It is better to use a cup to stir the medicine rather than a bottle, because if you use a bottle, the medicine will sink below and the concentration of the medicine will not be uniform. It is better to use a cup to stir the medicine rather than a bottle because if you use a bottle, the medicine will sink to the bottom and the concentration of the medicine will not be uniform.
Fourth, the adverse reactions of Simethicone
Occasionally constipation may be seen, the dose can be reduced and continued to take.