Lorazepam and alprazolam are both belong to the benzodiazepine sedative-hypnotic drugs, the adverse effects are very close, the specific which one adverse effects, and the sensitivity of the drug is related to the individual, can not be generalized, follow the doctor’s instructions can be taken. 1. Lorazepam can be used for short-term treatment of insomnia and anxiety disorders. The most common adverse reactions include malaise, vertigo, sedation, and unsteady gait, etc. Others include amnesia, memory impairment, euphoria, ataxia, weakness, convulsions, tremor, and vertigo. In use, it should be noted that hypersensitivity to the product and the ingredients contained in it, patients younger than 12 years old, patients with myasthenia gravis, patients with acute closed-angle glaucoma is prohibited. Use with caution during pregnancy and lactation, and avoid driving vehicles or operating machinery during the use of the drug. 2. Alprazolam can be used for the treatment of insomnia, short-term treatment of anxiety disorders, panic attacks and so on. Common adverse reactions include weakness, drowsiness, dizziness, etc. Other adverse reactions include jaundice, tremor, urinary retention, excessive sweating, dry mouth, palpitations and constipation. In use, it should be noted that those who are allergic to this product and the ingredients contained in it, patients younger than 18 years of age, acute alcoholism, myasthenia gravis, hepatic and renal impairment, patients with closed-angle glaucoma, etc. are prohibited from using it, and it is prohibited to drive vehicles and work at heights during the period of use, and it should be used with caution in pregnant women and during breastfeeding. Lorazepam and alprazolam are prescription drugs, should be taken under the guidance of a doctor, do not be negligent to avoid adverse reactions.