Girls with unbearable abdominal pain may be caused by gastric ulcer, acute gastroenteritis, appendicitis, pelvic inflammatory disease, etc., and need to be given medication, surgical treatment, etc. according to its cause. 1. Gastric ulcer: gastric mucosal damage to form an ulcer surface, causing abdominal pain, scopolamine can be given to relieve menstrual pain, if there is Helicobacter pylori infection, amoxicillin, clarithromycin, pantoprazole, colloidal bismuth and other medications. 2. Acute gastroenteritis: Eating unhygienic food triggers acute gastroenteritis, which can lead to unbearable abdominal pain. If there is bacterial infection, antibiotics such as norfloxacin and amoxicillin can be given, as well as medications such as montelukast and bifidobacteria. 3. Appendicitis: appendicitis cavity acute attack, the right lower abdominal pain is intolerable, should promptly consult the doctor, can follow the doctor’s instructions for surgical removal of the appendix treatment, improve the pain symptoms. 4. Pelvic inflammatory disease: pelvic inflammation caused by abdominal pain, can be given antibiotics, such as doxycycline, amoxicillin, cefuroxime and other anti-infective treatment. Girls with abdominal pain, it is recommended to seek medical attention, identify the cause of the disease, early treatment, so as not to delay the condition. Medication should follow the doctor’s instructions.