Vaccination and DMD hormone therapy

  Attenuated vaccines (live vaccines) such as measles, rubella, mumps, and varicella vaccines are contraindicated during hormone therapy. Hormones have an immunosuppressive effect, and at this time, vaccinations such as varicella and measles may cause severe symptoms if DMD involves respiratory function. Therefore, it is best to complete these vaccinations before hormone therapy.  About what is a live vaccine? What is a dead vaccine?  The details of routine scheduled vaccinations in China are as follows: If vaccinations are given while taking hormones, please double check the above vaccinations. Whether it is a live vaccine or not.  In addition, the following issues need to be noted for DMD hormone therapy: 1. The 23-valent polysaccharide pneumococcal vaccine recommended by the U.S. DMD for ages 2 and older should also be completed before the start of hormone therapy.  2. Inactivated dead vaccine can be administered in an immunosuppressed state, but the effect of the vaccine may have to be weakened.  3.According to the recommendation of the American Advisory Committee on Immunization Practices (ACIP), patients on hormone therapy can receive live attenuated vaccine in the following cases: (1) The duration of hormone use does not exceed 14 days.  (2) The amount of hormone use is low or moderate (no more than 20 mg of prednisolone per day).  (3) Long-term use of short-acting hormones on alternate days.  (4) The amount of hormone use is a physiological maintenance amount (supplemental therapy).  (5) Topical hormones for skin and ophthalmology, injections in joint cavities and tendons.  (6) The 2002 clinical guideline of the British Rheumatism Society defines the low dose as 10 mg per day. (4) For patients who are using high doses of hormones, how long to stop using hormones before receiving live attenuated vaccines, the ACIP 2011 recommends an interval of 1 month, while the clinical guideline of the British Rheumatism Society for vaccines states that an interval of 3 months is required. When it is necessary to discontinue hormones in order to receive live attenuated vaccine, a stepwise reduction to discontinuation is required, while observing for any worsening of muscle weakness symptoms.  5. Although prednisolone use below 10 mg daily is not a contraindication to live attenuated vaccination, the benefits and risks of vaccination with small doses of the hormone should be fully considered because there are no clear findings of a quantitative-effect relationship between the amount used and the degree of immunosuppression.