Locked-hole surgery began in the late 1990s. Using the principle that the whole chamber can be viewed through the foramen magnum, the surgeon’s extensive knowledge of neuroanatomy and skillful microsurgical techniques under the neuroendoscope and operating microscope are used to carefully design the surgical plan for each patient and use reasonable small surgical incisions and surgical accesses to complete the tumor resection surgery. Up to now, the neurosurgery department of Huashan Hospital has performed more than 490 supraorbital (transorbital) lockhole surgeries, including pituitary tumors, meningiomas, craniopharyngiomas, pituitary Rathke’s cysts, aneurysms and other tumors in the saddle area. Traditional craniotomy requires skin incision on one or both sides of forehead, which not only bleeds more, but also affects skin vascular reflux, nerve sensation and skin nutrition more seriously, and patients recover slowly after surgery. At the same time, traditional craniotomy exposes a large area of normal brain tissue and strains injury more commonly, which may cause unnecessary brain complications and sequelae. The lock-hole surgery usually only requires a 4-5 cm incision inside the eyebrow to complete the deep tumor resection, which ensures the total resection rate while saving many patients from the pain of traditional craniotomy with large bone flaps and does not affect the aesthetics of the head and face at all, and the incision inside the eyebrow is almost invisible three months after the surgery, which has given many patients more confidence in life. At the same time, the operation is safe, the postoperative recovery is fast, there is no need to remove stitches, the hospitalization time is obviously shortened, and the operation cost is saved accordingly, so it is generally welcomed and praised by the patients.