The cause of uterine fibroids is unclear. The disease occurs most often in women between 30 and 50 years of age, and is currently believed to be related to female hormones, genetic factors and cytokines. 1. Female hormones: including estrogen and progesterone. Currently, it is believed that the high sensitivity of leiomyoma tissue to local estrogen is one of the important factors in the development of uterine leiomyoma, and progesterone has the effect of promoting the mitosis of leiomyoma and stimulating the growth of leiomyoma. 2. Genetic factors: relevant researches show that 25%~50% of uterine fibroids have cytogenetic abnormality, such as rearrangement of the long arm of chromosome 12, transposition of the long arm fragments of chromosome 12 and 14, and partial deletion of the long arm of chromosome 7, and so on. 3. Cytokines: some growth factors may also play an important role in the growth of leiomyosarcoma, such as insulin-like growth factor, epidermal growth factor and so on. Women in the high-incidence age group should pay attention to regular medical checkups and regular diet. When uterine fibroids are detected, they should go to the hospital in time and be treated under the guidance of the doctor.