Patients with stage IV colon cancer usually need chemotherapy 6 to 8 times (cycles), some patients may be increased maintenance therapy, the number of times will be increased as appropriate, such as 10 times or more. The specific decision is based on the patient’s condition. Colon cancer is a common malignant tumor caused by heredity, bad dietary habits and other factors, and the main treatment for stage IV patients is chemotherapy. The main treatment method for stage 4 patients is chemotherapy, which is to use blood to make chemotherapy drugs reach the lesions to kill tumor cells and cure the disease. The number of chemotherapy treatments for stage IV patients is usually 6~8 times, with 21 days as a course of treatment. The commonly used chemotherapy regimens are XELOX (capecitabine + oxaliplatin); FORFOX4 regimen program (tetrahydrofolate + 5-fluorouracil + oxaliplatin). Drugs should be used under the guidance of a professional doctor, not blindly self-medication to avoid adverse effects.