Developmental brain injury refers to any genetic, intrauterine, or postnatal environmental factors that cause abnormal brain development or damage to the brain during the period from gestation to birth (mainly within 2-3 years of age), resulting in a series of neurological or behavioral deficits or defects. In recent years, basic and clinical research on developmental brain injury has made great progress, and this paper only discusses early identification and intervention. 1, early identification of developmental brain injury 1.1 high-risk factors: including environmental and biological factors. At present, various studies have confirmed that the main high-risk factors for brain injury include: a. perinatal asphyxia: whether prenatal, intrapartum, postnatal hypoxic asphyxia is an important factor in brain injury; b. preterm low birth weight: in recent years, due to the establishment of NICU wards and the improvement of treatment technology, the survival rate of preterm infants has increased significantly, and the incidence of CP in preterm low birth weight infants has also increased accordingly. Prematurity and low birth weight are very important risk factors for cerebral palsy CP in children.C. Pathological jaundice: Severe pathological jaundice can lead to damage of the nucleus accumbens and produce related neurological symptoms, and is a risk factor for pediatric tardive dyskinesia CP. 1.2 Early signals: The detection of early signals of brain injury can be observed in four aspects, including lagging motor developmental milestones, persistence of primitive reflexes, postural abnormalities, and abnormal neurological examination. 1.2.1 Motor development milestones lagging behind: where head control, as the first milestone in gross motor development, has considerable importance in early identification. For example, vertical head, normal infants can already erect their heads in February and can erect steadily in March; prone head raising is more responsive to infants’ ability to actively raise their heads. Normal infants can lie prone since a few days after birth, but infants within 1 month of lying prone can not lift their own heads, but can only instinctively struggle to turn their faces to the side, and by 2 months of age can slightly lift their heads and front chests, and by 3 months of age can lift their heads very steadily, and front chests can be lifted off the table. 1.2.2 Continued primitive reflexes: including sucking reflex (sucking reflex), foraging reflex (rooting reflex), hugging reflex (Moro reflex), grasp reflex (grasp reflex), stepping reflex (stepping reflex), neck tonic reflex (nuchal reflex), and lateral bending reflex. reflex, incurvation reflex, asymmetrical tonic neck reflex, crossed extensor reflex, and more than 20 other reflexes. By examining the infant’s primitive reflexes, we can initially determine the infant’s neurological development and neuropsychiatric condition. The four major physiological reflexes commonly used in newborns are the sucking reflex, the feeding reflex, the holding reflex, and the hugging reflex. Most primitive reflexes fade after a few months of life, but their delayed fading or persistence is often an important indicator [2,3]. Also, different abnormalities of primitive reflexes have some significance in predicting different types of CP. For example, the primitive reflexes that are more suggestive of tardive CP include foot grip, lateral bending reflex and asymmetric cervical tension firing; while the primitive reflexes that are more suggestive of spastic CP include grip reflex and crossed leg extension reflex. 1.2.3 Neurological examination (1) Arousal: over-excitation or over-inhibition, both may be abnormal. (2) Spontaneous movements (GMs) spontaneous movement evaluation originated in Australia and was first applied in pediatric clinics in Europe, America and Japan, and has been applied in China in recent years. The evaluation includes: overall evaluation (including evaluation of movement complexity, fluency and variability) and detailed evaluation (analysis of movement speed, amplitude, characteristics, sequence, spatial position, fluency and grace, beginning and end, fine movement of hands and feet). The sensitivity of GMs for CP prediction was reported to be 100%, and the specificity for spastic CP prediction was 92.5-100%. (3) Head circumference: The measurement of head circumference can reflect the growth of brain volume, so it is important for the determination of brain injury. It is important to continuously track the head circumference of high-risk children. The normal standard of head circumference is the mean value of head circumference ± 2 SD for children of the same age. e.g. head circumference at birth 6 times/sec, amplitude of vibration