Clindamycin and amoxicillin needles belong to different classes of antibiotics, can not simply compare which one is more effective, in the treatment should be based on the patient’s infected germs medication. 1. Clindamycin is a macrolide antibiotic used for the treatment of oral and mucosal infections caused by anaerobic bacteria, biliary tract infections caused by gram-positive cocci, etc. It is the drug of choice for osteomyelitis caused by Staphylococcus aureus. The mechanism of action is irreversible binding to the 50S subunit of the bacterial ribosome, inhibiting bacterial protein synthesis. Adverse reactions such as nausea, vomiting, rash and itching may occur with the use of this drug, and it is contraindicated for those who are allergic to clindamycin. 2. Amoxicillin is a β-lactam antibiotic, clinically used for respiratory tract and biliary tract infections caused by sensitive bacteria, typhoid fever treatment, but also for chronic gastritis and peptic ulcer treatment. Adverse reactions such as nausea and vomiting can occur. A history of allergy or hypersensitivity to amoxicillin is contraindicated. It is recommended to standardize the use of medication under the guidance of a doctor.