Positive anticardiolipin antibodies may be seen in systemic lupus erythematosus, antiphospholipid antibody syndrome, etc. The cause of the disease should be further clarified and medication and other treatments should be provided to address the cause. Anti-cardiolipin antibody is a kind of autoantibody, which should be negative under normal condition and positive is an abnormal result. Among them, autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, primary thrombocytopenia, and antiphospholipid antibody syndrome are closely related to anticardiolipin antibody, and the antibody is also seen in liver cirrhosis, thrombosis and other diseases. Positive anticardiolipin antibodies should be further discussed with the physician and complete the blood sedimentation, autoantibody profile, ultrasound, X-ray and other auxiliary examinations to clarify the cause of the antibody abnormality and target treatment. If the patient has autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis, the treatment should be based on the use of glucocorticoid such as prednisone and immunosuppressant such as methotrexate. Laboratory test results should be interpreted by a professional physician, and it is recommended that patients with positive anticardiolipin antibodies go to the rheumatology and immunology departments of regular hospitals for detailed consultation and treatment in accordance with the doctor’s instructions, and do not use medication on their own.