Pain below the knee requires targeted treatment for specific conditions. There are mainly proximal patellar ligament injury, arthritic disease, chondromalacia patella, infrapatellar fat pad inflammation, meniscus injury and osteoarthritis, etc., which can be treated by conservative, medication and surgery. 1. Proximal patellar ligament injury: manifested as pain in the lower pole of the patella, the intersection of the patella and patellar tendon is injured or strained, and localized pressure and pain is obvious. Flexibility exercise should be strengthened. When the pain can be hot compress physiotherapy, but also oral celecoxib and other anti-inflammatory pain medication. 2. Arthritic diseases: mainly gouty arthritis, rheumatoid arthritis and rheumatoid arthritis can cause pain below the knee. Need oral anti-gout treatment, oral colchicine. Anti-rheumatic treatment oral celecoxib and other drugs. 3. Chondromalacia patella: it is the chondromalacia patella surface due to chronic injury, cartilage swelling, damage to the formation of patellofemoral joint osteoarthropathy. It needs physical therapy, hot compresses and anti-inflammatory painkillers such as ibuprofen. 4. Infrapatellar fat pad inflammation: lesions in the infrapatellar fat pad tissue, for sterile inflammation. Hot compresses and physical therapy are needed. When the inflammation is severe, oral medication such as Loxoprofen sodium should be taken. 5. Meniscus injury: Anterior horn of meniscus injury will appear below the knee pain. Minimally invasive surgical arthroscopy is needed for meniscus suturing or meniscoplasty. 6. Osteoarthritis: pain below the knee occurs due to degenerative lesions that destroy bone in the joint. Treatment requires anti-inflammatory painkillers such as ibuprofen. In severe cases, artificial joint replacement surgery can be performed. If you have pain below the knee, it is recommended that you consult a doctor in time and do not delay treatment.