The most serious complications of portal cirrhosis are as follows: 1. Rupture of esophagogastric fundic varices and bleeding: cirrhosis can lead to an increase in portal vein pressure in patients, which can lead to a subsequent increase in pressure in all branches of the ileohepatic veins, including the esophagogastric fundic vein, and may lead to esophagogastric varices. The risk of bleeding increases if the patient eats harder foods at this time. These patients have a large amount of bleeding and a rapid onset, which is the most serious complication and may endanger the patient’s life at any time if left untreated. 2. Hypersplenism: Blood from the spleen mainly flows back into the liver, and splenic congestion and hypersplenism result from portal hypertension. Hypersplenism destroys the patient’s white blood cells, red blood cells and platelets, leading to bleeding infections, etc.; 3. Hepatic encephalopathy: portal hypertension may induce hepatic encephalopathy.