Creatinine is a metabolic product of human body, which is mainly filtered through the glomerulus. Any disease that causes glomerular damage or reduces glomerular filtration rate can cause high renal creatinine. 1, the change of glomerular effective filtration pressure, patients with hypertension because of the narrowing of small glomerular arteries into the glomerulus due to sclerosis, capillary pressure is reduced. When a large amount of intravenous infusion is given, plasma protein is diluted and plasma colloid osmotic pressure decreases. When urethral obstruction occurs, such as urinary tract stones, it makes the intracapsular pressure of the glomerulus rise and the filtration pressure decrease, these reasons lead to the decrease of creatinine filtration and creatinine will be high. 2.In acute glomerulonephritis, the glomerular filtration membrane endothelium thickens, capillary occlusion, filtration area decreases, and the creatinine generated cannot be metabolized quickly enough to cause high values. 3, the human body in strenuous exercise or go to some plateau area, due to the relative lack of oxygen, renal vasoconstriction, blood flow decreased, more than the metabolism of creatinine will also decline, resulting in high renal creatinine. 4, in the treatment of some diseases need to take drugs, these drugs have more than a certain impact on kidney function, after taking drugs for a period of time will have abnormal creatinine monitoring. Therefore, there are many reasons for high creatinine, so we should analyze the specific reasons and review the kidney function regularly.