Aminoglycosides are antibacterial drugs, the representative drugs are penicillin and amikacin, mainly used for intestinal infections. The adverse reactions of aminoglycoside antibacterial drugs are mainly manifested in the following aspects. 1. gastrointestinal reactions, mainly manifested as nausea, vomiting, abdominal distension and loss of appetite. It should be taken after meals to reduce the above-mentioned adverse reactions. 2, nephrotoxicity, manifested as hematuria, reduced urine volume, etc.. It is recommended that we should check the renal function before applying aminoglycosides, and we should drink a lot of water, at least 1500mL per day, to reduce the nephrotoxicity of the drug. 3, ototoxicity, mainly manifested as hearing loss, tinnitus, vertigo, etc., especially in newborns is not recommended, and the hearing should be reviewed regularly during the application period.