Total IgE refers to a kind of immunoglobulin E. Normal reference value is 0.1~0.9mg/L. High total IgE may be due to allergy, parasitic infection, blood system disease, etc. 1. Allergy: Including food allergy, inhalation of pollen, dust and other allergens, which combine with immunoglobulin E, causing hypersensitivity reaction and elevated IgE, which mainly produces symptoms such as rashes, asthma, rhinitis and so on. 2. Parasitic infections: including helminth infections and trematode infections, such as roundworms, hookworms, liver fluke, lung fluke, etc., can cause IgE elevation. 3. hematologic diseases: such as multiple myeloma of IgE type, malignant proliferative disease of plasma cells. The abnormal proliferation of clonal plasma cells in the bone marrow, IgE can be elevated, but less common. It is usually accompanied by generalized skeletal destruction, manifestations of microcirculatory disorders, and even cardiovascular and cerebrovascular diseases such as cerebral infarction. When the total IgE is high, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, clarify the cause with the help of the doctor, and carry out targeted treatment or therapy.