Sulfonylureas and metformin are ineffective, considering obesity, bad dietary habits and insulin secretion function decline, according to the cause of the disease from the diet as well as medication to do some adjustments, if necessary, need to inject insulin. 1. Body obesity: If the body is too obese during oral hypoglycemic drugs, it may lead to the failure of hypoglycemic drugs. In this case, you can control your weight within the normal range by increasing your activity appropriately. 2. Bad dietary habits: If you take oral hypoglycemic drugs for a long time to eat some high-sugar, high-fat food, easy to affect the effect of hypoglycemic, so in the taking of hypoglycemic drugs during the diet should be improved, try to low-fat, low-salt, low-sugar as the principle. 3. Decline of insulin secretion function: the unsatisfactory effect of taking hypoglycemic drugs may be due to the weakening or gradual decline of insulin secretion function, this kind of patients need to adjust the dosage of hypoglycemic drugs appropriately or inject insulin to lower sugar. Taking sulfonylurea hypoglycemic drugs or metformin hypoglycemic drugs should be carried out under the guidance of professional physicians to avoid unauthorized use of drugs.