The main adverse reactions of Marfan are as follows: 1. Myelosuppression is mainly dose-limiting toxicity, which is related to the dose and the number of cycles of medication, mainly manifested as leukocytopenia, thrombocytopenia and anemia. The duration of myelosuppression is related to the patient’s age, physical condition, food intake and the number of drug cycles. 2. Gastrointestinal reactions may occur in patients with loss of appetite, reduced diet, nausea, vomiting, etc. No significant gastrointestinal reactions may occur with low doses of continuous drug administration. 3. Peeling, dermatitis, stomatitis, and pulmonary fibrosis, etc.