Usually there are several reasons for epidermal flesh pain on the body as follows: First, the most common factor is infectious. When the skin is infected by contact infection, especially bacterial, viral and fungal infections, there will be peripheral cellulitis. In the presence of cellulitis, there will be redness, swelling, heat, pain, joint dysfunction and other conditions around it. Secondly, it is related to peripheral neurosensitivity and peripheral neuritis, especially diabetic patients are prone to peripheral neuritis which leads to epidermal flesh pain on the kidney. Third, non-infectious factors, such as dermatomyositis and rheumatoid arthritis, can also occur when epidermal flesh pain. Fourth, viral factors of the skin, such as shingles, can also lead to epidermal flesh pain on the body. Fifth, the body will release inflammatory factors, such as leukotrienes, bradykinin, prostacyclin, etc., when the peripheral infection, such peripheral infection of inflammatory factors will release inflammatory factors in the epidermis of the body, will infect the surrounding will also lead to epidermal flesh pain.