Blood pressure is constantly changing over a 24-hour period, and early morning is usually the time of day when blood pressure levels are highest. Early morning blood pressure is defined as home blood pressure measurements taken within 1 hour of waking up, before taking medication, before breakfast, or 2 hours after waking up or between 6:00 and 10:00 a.m. as recorded by ambulatory blood pressure. Early morning blood pressure is associated with target organ damage, with atherosclerosis and left ventricular hypertrophy, and is strongly associated with kidney damage. Studies have shown that the incidence of myocardial infarction and stroke is highest in the early morning hours. For the vast majority of patients, early morning blood pressure is a vane to control blood pressure throughout the day and 24 hours. By monitoring blood pressure in the early morning before taking medication, it is a good way to determine whether a patient’s antihypertensive treatment regimen is truly controlling blood pressure for 24 hours. Early morning blood pressure management starts with early morning blood pressure monitoring and assessment to understand the early morning blood pressure control and assess the effect of antihypertensive treatment. Home blood pressure measurement, 24-hour ambulatory blood pressure, and in-office blood pressure measurement are three methods that can be used for early morning blood pressure monitoring and assessment. Because home blood pressure monitoring can be performed frequently or even daily, home blood pressure monitoring is the best way to observe blood pressure control during antihypertensive treatment. Home blood pressure measurement methods: (1) should be performed within 0.5 to 1.0 hours after waking up, usually between 6:00 and 10:00 a.m.; (2) blood pressure should be measured before taking medication and before breakfast, if possible; (3) the bladder should be emptied and the sitting position should be adopted, if possible, before blood pressure measurement. The normal value of early morning blood pressure, when home blood pressure monitoring or ambulatory blood pressure monitoring early morning blood pressure ≥ 135/85mmHg office blood pressure ≥ 140mmHg is considered early morning hypertension. Four principles of early morning blood pressure treatment protocol:Early morning blood pressure control in hypertensive patients is still not optimistic and should be used to improve overall blood pressure management and more effectively prevent cardiovascular and cerebrovascular events through effective assessment and management of early morning blood pressure. Currently, there are many recommended once-a-day antihypertensive drugs, but in fact some of them are difficult to achieve “continuous blood pressure control for 24 hours”. (1) Use drugs with a half-life of 24 hours or more and a truly long-acting once-daily dose that can control blood pressure for 24 hours, so as to avoid poor medical control of early morning blood pressure due to improper choice of treatment regimen; (2) Use drugs that are safe for long-term adherence and can control blood pressure for each 24-hour period to improve patient compliance; (3) For patients with pure (3) For patients with early morning hypertension, the timing of the medication can be adjusted; (4) Use drugs that are well documented in clinical trials for cardiovascular benefit and can actually reduce cardiovascular events in the long term. Choosing a true molecular long-acting antihypertensive drug helps patients improve adherence to more effective control of early morning blood pressure.