Lupus nephritis urine protein three plus belongs to the category of massive proteinuria, if no kidney puncture biopsy has been done, and there are no contraindications suggesting a kidney puncture biopsy to clarify the specific pathological type and activity level. For the treatment of lupus nephritis, the first choice of hormone combined with immunosuppressive therapy, more commonly used are methylprednisolone, prednisone, cyclophosphamide and mycophenolate. Methylprednisolone can be applied as shock treatment for three days, followed by prednisone in full dose, and then gradually reduced after one month, to the minimum dose of 2-3 tablets per day over a period of six months. And cyclophosphamide is applied 1g per month for six months, and after six months, if the effect is not good you can switch to mycophenolate, or you can directly use mycophenolate to induce remission and maintain remission. In addition to the core therapeutic drugs mentioned above, hydroxychloroquine can be applied to regulate immunity, low-molecular heparin anticoagulation, dipyridamole antiplatelet aggregation, atorvastatin to lower lipids, and human albumin transfusion to correct hypoproteinemia when necessary. The treatment of lupus nephritis is a systematic and long-term treatment.