Oral mucosal fibrosis generally refers to fibrous changes in the oral submucosa, the disease is irreversible lesions, it is generally difficult to return to normal, drug therapy can provide some relief of symptoms, including glucocorticoids, antifibrotic drugs, peripheral vasodilators, etc., as follows. 1. Glucocorticoid: Glucocorticoid can anti-inflammatory and inhibit the process of fibrosis, such as hydrocortisone, triamcinolone acetonide, betamethasone, dexamethasone and so on. 2. Anti-fibrotic drugs: can reverse the process of fibrotic degeneration fibrosis in the oral submucosa, such as dexamethasone, hyaluronidase and pancreatic coagulation protease combined use. 3. Peripheral vasodilators: can improve the microcirculation in the lesion area to enhance the clinical efficacy and alleviate the symptoms, such as hexacosanol, buthlodipine, bupropion hydrochloride and so on. All of the above medications should be used under the guidance of a doctor, and it is recommended to go to the hospital to receive regular treatment.