The difference between hydroxymetazoline hydrochloride and naphazoline hydrochloride are different indications, different range of applicable people, etc., but the adverse effects are similar and the contraindications are partially similar. Hydroxymetazoline Hydrochloride is mainly used for the treatment of sinusitis, hypertrophic rhinitis, acute and chronic rhinitis, allergic rhinitis. It is indicated for adults and children over 6 years of age. Adverse reactions such as rebound nasal congestion, mild burning sensation, pins and needles, dizziness and headache, and increased heart rate may occur. The drug is contraindicated in pregnant women and children under 2 years of age, atrophic rhinitis, people with dry nasal passages, and people who are allergic to the drug. Naphazoline hydrochloride is mainly used for the treatment of acute and chronic rhinitis, allergic and inflammatory nasal congestion for adults. Its adverse effects are similar to those of hydroxymetazoline hydrochloride. The drug needs to be used with caution in pregnant women, hypertension, coronary heart disease, and hyperthyroidism. The drug is contraindicated in people with atrophic rhinitis, dry nasal passages, and those who are allergic to naphazoline hydrochloride. It is recommended to use the drug under medical supervision.