Sore and weak legs in tuberculosis may be related to the stimulation of Mycobacterium tuberculosis, or it may be caused by the adverse reaction of medication or malnutrition. 1. Mycobacterium tuberculosis stimulation: Tuberculosis is mainly caused by Mycobacterium tuberculosis infection, which attacks the patient’s body and releases more tuberculosis toxins, which may cause leg soreness and weakness, and may also be accompanied by loss of appetite, night sweats and other symptoms. 2. Adverse reactions to medication: the disease is a chronic disease, patients need to apply anti-tuberculosis drugs for a long time, which may produce adverse reactions, which may show weakness and aching legs, and may be accompanied by low fever, nausea and other symptoms. 3. Malnutrition: Tuberculosis is a chronic consumptive disease, which can easily lead to loss of appetite and weight loss, and over time, it may cause malnutrition, which may show weakness and aching legs, and may be accompanied by emaciation, weakness and other symptoms. Tuberculosis leg pain and weakness may also be caused by other reasons, should actively cooperate with the doctor for standardized treatment and regulation.