The bottom of the foot grows a hard lump like callus, may be callus, metatarsal warts, corns, etc., need to carry on the cause of drug treatment, surgical treatment, physical therapy, etc.. 1. For the callus caused by long-term skin pressure and friction leading to local keratin hyperplasia and hardening, you need to follow the doctor’s instructions for external use of urea cream, vitamin A cream and other drugs to remove keratin; liquid nitrogen freezing and other physical methods can remove the hyperplasia of the stratum corneum. 2. For metatarsal warts caused by viral infection, 0.7% of the plantar warts, 0.5% of the onychomycosis and other ointments should be used externally as prescribed by the doctor; freezing or laser treatment can remove the warts; surgery can be used to remove the warts, if necessary. 3. For the foot skin is subjected to long-term extrusion or friction caused by the skin local conical thickening of the corns, need to comply with the doctor’s instructions for the external use of corns cream and other exfoliation; liquid nitrogen cryotherapy, laser treatment can eliminate the thickening of the keratin. It is recommended that people who have a hard lump on the bottom of the foot like a callus go to the hospital in a timely manner, to clarify the cause of the disease, under the guidance of the doctor for standardized treatment.