Cholestasis affects the fetus, mainly in the following aspects: 1, central nervous system: cholestasis mainly affects the fetal brain, there will be stunted phenomenon, which in turn causes central nervous system symptoms, namely, kernel jaundice, resulting in fetal mental retardation, lethargy, coma and so on. Cholestasis due to the corresponding pathological factors, self-factors lead to pregnant women silt, that is, bilirubin continues to rise, at this time the fetal blood-brain barrier is not well developed, can be passed freely; 2, other aspects: bilirubin is a more damaging substances, to the patient’s heart can inhibit the pattern of activity, if the liver is located in the inhibition of synthesis, decomposition, metabolism, and to the kidneys will affect the formation of urine, affecting the function of the kidneys. Therefore, when patients find bilirubin, it is recommended to take positive measures in time to bring the amount of bilirubin to the normal level, so that the fetus can have a better development.