Taking amlodipine benzenesulfonate tablets for 15 years is not necessarily harmful. This drug can be taken for a long time, some patients may have adverse reactions such as flushing, edema, dizziness, tremor, thrombocytopenic purpura, etc., and it is enough to stop the drug or change the drug in time. Amlodipine benzenesulfonate tablets is a kind of calcium antagonist, which can be used in the treatment of hypertension, chronic stable angina and variant angina. It is well tolerated by most patients and can be taken for long periods of time, and 15 years of taking it does not necessarily mean that harm will occur. The common adverse reactions of amlodipine benzenesulfonate tablets include flushing, fatigue, edema, vertigo, headache , abdominal pain, nausea, panic, drowsiness, etc.; less frequent adverse reactions include dry mouth, hypotension, syncope, hypertonia, tremor, breast enlargement, gingival hyperplasia, thrombocytopenia, erectile dysfunction; rare allergies, jaundice, etc.. This drug is contraindicated in people who are allergic to any of its components. In conclusion, if the patient can tolerate the drug without significant adverse reactions, taking it for 15 years will not be harmful. However, the patient’s own situation is gradually changing, to be safe, should pay attention to the monitoring of blood pressure during the use of the drug, regular review, to avoid adverse drug reactions, or the patient’s resistance to the drug, resulting in poor control of blood pressure and other situations. Amlodipine benzenesulfonate tablets, please follow the doctor’s instructions to take, not blindly self-administered.