Targeted drugs are not usually used to treat pain from bone metastatic cancer. Targeted drug is a kind of drug that is aimed at tumor-specific targets, which is more therapeutic and has fewer side effects. However, the molecular targeted drug’s are for tumors and have no obvious effect on cancer pain. For the treatment of bone metastatic cancer pain, medication and other treatment means can be used. 1. Drug treatment: For the treatment of cancer pain, it is necessary to grasp the principle of three-step analgesic treatment for cancer pain. Firstly, non-invasive, oral drug administration. Give drugs according to the ladder ~ use non-steroidal drugs (aspirin) for mild pain, use weak opioids (codeine) for moderate pain, and use strong opioids (morphine) for severe pain. 2. Other treatments: In addition to the treatment of drugs, there are other treatments that can be used only. Such as nerve block therapy: peripheral nerve block, epidural nerve block; nerve radiofrequency therapy; spinal cord electrical stimulation therapy; intrathecal drug injection therapy. Drug treatment should be applied reasonably under the guidance of a physician, do not self-medicate.