What kind of medication should be used for soreness at the outer thigh root cannot be generalized, it may be caused by physiological factors such as fatigue, or pathological factors such as aseptic inflammation of the hip joint, osteonecrosis of the femoral head, osteoporosis, and so on, and specific medication should also be chosen according to the cause of the disease. 1. Physiological factors: due to long time walking, running or heavy physical labor, it can cause thigh muscle fatigue, lactic acid accumulation, resulting in soreness at the root of the thigh, which can be gradually relieved with proper rest, and does not require special treatment. 2. Aseptic inflammation of the hip joint: when the hip joint is over-exercised and improperly used, aseptic inflammation such as synovitis and arthritis can occur, causing soreness and pain at the outer thigh root, which can be relieved by taking non-steroidal drugs such as acetaminophen tablets, diclofenac sodium, celecoxib, and so on, which can play the role of anti-inflammatory and analgesic. 3. Necrosis of femoral head: If necrosis of femoral head causes soreness on the outer side of thigh root, you can use non-steroidal drugs such as diclofenac sodium, ibuprofen, etc. to relieve the pain, and you can also use drugs such as zoledronic acid sodium injection to treat the pain. 4. Osteoporosis: when the lack of calcium in the body can cause osteoporosis, there will be soreness and weakness of the limbs, you can take calcium carbonate, calcium gluconate and other oral calcium supplements, while supplementing vitamin D to promote the absorption of calcium, but also oral alendronate sodium and other drugs to treat osteoporosis. Causes of thigh root lateral soreness more causes, when the discomfort symptoms, should go to the hospital in time for examination, to clarify the cause of the disease, targeted treatment. The above medications should be used in a standardized manner under the guidance of a professional physician, and be aware of adverse reactions.